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Leveraging phenotypic and hospitalization data from UK Biobank, this study investigated the prospective and causal association of physical frailty and its components with MASLD incidence, as well as the multiplicative and additive interactions with covariates. Then, capitalizing on high-throughput metabolomics data, we conducted a metabolome-wide association analysis to identify frailty-associated metabolites and dissect their role in mediating MASLD risk. Last, we reran the above analyses using MRI-derived PDFF as a secondary outcome and validated the association analysis on matched data using a propensity score matching procedure. Icons were made from www.svgrepo.com/ .

Journal: Science Advances

Article Title: The metabolomic signatures mediate associations between physical frailty and metabolic dysfunction–associated steatotic liver disease

doi: 10.1126/sciadv.aeg4939

Figure Lengend Snippet: Leveraging phenotypic and hospitalization data from UK Biobank, this study investigated the prospective and causal association of physical frailty and its components with MASLD incidence, as well as the multiplicative and additive interactions with covariates. Then, capitalizing on high-throughput metabolomics data, we conducted a metabolome-wide association analysis to identify frailty-associated metabolites and dissect their role in mediating MASLD risk. Last, we reran the above analyses using MRI-derived PDFF as a secondary outcome and validated the association analysis on matched data using a propensity score matching procedure. Icons were made from www.svgrepo.com/ .

Article Snippet: Metabolomic analysis was performed on baseline EDTA plasma samples from a randomly selected subset of participants using a high-throughput NMR spectroscopy platform provided by Nightingale Health Ltd. ( ).

Techniques: High Throughput Screening Assay, Derivative Assay